China's urea import and export statistics in April

In April 2008, China exported a total of 724,900 tons of urea, the total amount of exports was 255,730,966 USD, and the average unit price was 353 USD/ton. Compared with the same period in 2007, the export volume increased by 593,200 tons, an increase of 450.27%, the export amount increased by 216,096,917 US dollars, and the average unit price increased by 51 US dollars/ton.
In April 2008, the total import volume was 18.06 tons and the total import amount was US$10,489.

Macitentan is an orally available dual endothelin receptor (ETR) antagonist with potential antihypertensive and antineoplastic activity. Upon administration, macitentan and its metabolites block the binding of endothelin isoform 1 (ET-1) to type-A and type-B ETR on both the tumor cells and the endothelial cells in the tumor vasculature. This prevents ET-1 mediated signaling transduction which may decrease tumor cell proliferation, progression, and angiogenesis in tumor tissue. ET-1, a potent vasoconstrictor that plays an important role in inflammation and tissue repair, is, together with its receptors, overexpressed varyingly in many tumor cell types.

Macitentan is an endothelin receptor antagonist that is used in the therapy of pulmonary arterial hypertension (PAH). Macitentan has been associated with a low rate of serum enzyme elevations during therapy, but has yet to be implicated in cases of clinically apparent acute liver injury.

Macitentan API

Macitentan Api,Macitentan Cas 441798-33-0,Macitentan Actelion-1 Opsumit,Macitentan Api Project Actelion-1

 Shandong Haohong Biotechnology Co., Ltd. , https://www.haohongpharma.com